【国民娱乐每日礼金gm777.top,金祥彩票官网网址中大奖】我们为您提供金祥彩票官网网址注册,金祥彩票官网网址投注,金祥彩票官网网址app,金祥彩票官网网址平台,巨华彩票开户,充提快速,操控简单,为金祥彩票官网网址彩民服务!

您的位置>> 金祥彩票官网网址 > 新聞動態 > 學術動態 > 閱讀正文
學術動態
學術報告第163場 茅涵斌教授的學術報告
發表于: 2019-09-04 12:54  點擊:

報告題目:Single-Molecule Mechanochemical Sensing

報 告 人: Prof. Hanbin Mao(茅涵斌)

Kent State University, USA

報告地點:無機-超分子樓圓形報告廳一樓

報告時間:2019年09月05日 上午9:30(星期四)

邀 請 人 :張文科教授

報告人簡介

茅涵斌教授金祥彩票官网网址,1995畢業西醫科大學學院物化學專業金祥彩票官网网址。隨后分在美國波士大學和德克A&M大學士和博士學位。2003年至2005年在加州大學伯克利分校從事博士后研究,現為美國肯特州立大學教授金祥彩票官网网址金祥彩票官网网址。茅涵斌教授主要研究方向包括: 1. 利用分子激光光和磁術進行的生物大分子研究金祥彩票官网网址,主要內容包括生物大分子構象研究、生物分子相互作用機理的研究;2 .利用分子技構建超靈敏生物感器等。迄今在Nature Chem., Nature Nano., PNAS金祥彩票官网网址,JACS, Angewandte Chemie, Nucleic Acids Research尖學期刊上表文章數十篇。

Single-Molecule Mechanochemical Sensing

Hanbin Mao

Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242

Advanced Materials and Liquid Crystal Institute, Kent State University, Kent, OH, 44242

ABSTRACT

Traditional biosensors constitute two elements, molecular recognition and signal amplification. The first element determines specificity of the sensing while the second component decides sensitivity of the sensing. In a typical setup, these two components are spatiotemporally decoupled. In the widely used ELISA strategy, for example, chemical amplifications are usually performed once the molecular recognition is complete. As amplification requires additional time to accomplish, it is challenging for this method to detect analyte in real time, which is highly desirable when the ligand of interest has transient lifetimes. Another problem for decoupled sensing components lies in the fact that extra steps are required to prevent the cross-talks between the two components. These additional steps bring new errors for the sensing, deteriorating the signal-to-noise level.

In this presentation, I will discuss a new sensing strategy that exploits mechanochemical coupling inside biomacromolecular templates, DNA in particular. Mechanochemical coupling reflects the interaction between covalent/non-covalent chemical bonds in a molecule and mechanical stress experienced by the molecule. It is a key subject in the newly emerged field, mechanochemistry, which has led to a number of exotic applications in materials chemistry. However, mechanochemical principles have not been well explored in chemical sensing. Using force-based single-molecule techniques, such as optical tweezers, our group has been able to follow change in the tension of individual DNA templates upon recognition of targets. The mechanochemical coupling occurs instantaneously, enabling real time detection of analytes. Since the template we use is single-molecular in nature, the ultimate single-molecule sensitivity can be achieved. Combined with a microfluidic platform, this sensing strategy has allowed us to detect picomolar concentrations of specific targets in biological samples.




版權所有:吉林大學化學學院  ? 2019 郵箱:chembg@jlu.edu.cn
地址:吉林省長春市前進大街2699號 郵編:130012


金祥彩票官网网址